synapse/docs/systemd-with-workers/system/matrix-synapse.service

[Unit]
Description=Synapse master

# This service should be restarted when the synapse target is restarted.
PartOf=matrix-synapse.target
ReloadPropagatedFrom=matrix-synapse.target

[Service]
Type=notify
NotifyAccess=main
User=matrix-synapse
WorkingDirectory=/var/lib/matrix-synapse
EnvironmentFile=/etc/default/matrix-synapse
ExecStartPre=/opt/venvs/matrix-synapse/bin/python -m synapse.app.homeserver --config-path=/etc/matrix-synapse/homeserver.yaml --config-path=/etc/matrix-synapse/conf.d/ --generate-keys
ExecStart=/opt/venvs/matrix-synapse/bin/python -m synapse.app.homeserver --config-path=/etc/matrix-synapse/homeserver.yaml --config-path=/etc/matrix-synapse/conf.d/
ExecReload=/bin/kill -HUP $MAINPID
Restart=always
RestartSec=3
SyslogIdentifier=matrix-synapse

[Install]
WantedBy=matrix-synapse.target